Compared with first-generation antipsychotics, second-generation agents typically have fewer of which?

Compared with first-generation antipsychotics, second-generation agents typically have fewer of which?

• A. Not as many side effects as first-generation antipsychotics
• B. More side effects than first-generation
• C. No side effects
• D. Less effective for positive symptoms

Answer: (A)

Second-generation antipsychotics have fewer extrapyramidal, or motor, side effects than first-generation agents because they antagonize both dopamine D2 receptors and serotonin 5-HT2A receptors. This combination preserves antipsychotic effectiveness while reducing motor symptoms likeParkinsonism, dystonia, and akathisia. They can still cause other adverse effects, notably metabolic issues such as weight gain, lipid changes, and blood sugar elevations. For positive symptoms, they are typically as effective as, or more effective than, first-generation drugs, not less. So the statement that they have not as many side effects overall—especially in terms of motor side effects—is the best choice.

Second-generation antipsychotics have fewer extrapyramidal, or motor, side effects than first-generation agents because they antagonize both dopamine D2 receptors and serotonin 5-HT2A receptors. This combination preserves antipsychotic effectiveness while reducing motor symptoms likeParkinsonism, dystonia, and akathisia. They can still cause other adverse effects, notably metabolic issues such as weight gain, lipid changes, and blood sugar elevations. For positive symptoms, they are typically as effective as, or more effective than, first-generation drugs, not less. So the statement that they have not as many side effects overall—especially in terms of motor side effects—is the best choice.