COX II is primarily targeted to combat which process?

COX II is primarily targeted to combat which process?

• A. Converts Arachidonic Acid -> Prostaglandins used for Inflammation; MAIN Target to COMBAT Inflammation
• B. GI Mucosal Protection
• C. Renal Blood Flow
• D. Platelet Aggregation

Answer: (A)

COX-2 is an inducible enzyme that goes up at sites of inflammation, where it converts arachidonic acid into prostaglandins that drive inflammation, pain, and fever. By inhibiting COX-2, you reduce these proinflammatory prostaglandins, directly blunting the inflammatory process and its symptoms. The other roles—protecting the stomach lining, supporting platelet function, and helping maintain renal blood flow—are mainly the domain of COX-1. So targeting COX-2 serves to combat inflammation while preserving the protective and maintenance functions largely handled by COX-1.

COX-2 is an inducible enzyme that goes up at sites of inflammation, where it converts arachidonic acid into prostaglandins that drive inflammation, pain, and fever. By inhibiting COX-2, you reduce these proinflammatory prostaglandins, directly blunting the inflammatory process and its symptoms. The other roles—protecting the stomach lining, supporting platelet function, and helping maintain renal blood flow—are mainly the domain of COX-1. So targeting COX-2 serves to combat inflammation while preserving the protective and maintenance functions largely handled by COX-1.