Penicillin G is typically administered by which route?

Penicillin G is typically administered by which route?

• A. Intramuscular
• B. Oral
• C. IV
• D. Subcutaneous

Answer: (C)

Penicillin G is destroyed by stomach acid and is poorly absorbed when taken by mouth, so reliable systemic exposure requires a parenteral route. Intravenous administration provides immediate, complete bioavailability and rapid therapeutic levels, which is essential for serious infections. While intramuscular administration is possible, absorption from muscle is slower and more variable, making IV the preferred option for achieving prompt, predictable blood levels. Subcutaneous administration is not commonly used for Penicillin G, and oral administration is generally ineffective due to gastric degradation.

Penicillin G is destroyed by stomach acid and is poorly absorbed when taken by mouth, so reliable systemic exposure requires a parenteral route. Intravenous administration provides immediate, complete bioavailability and rapid therapeutic levels, which is essential for serious infections. While intramuscular administration is possible, absorption from muscle is slower and more variable, making IV the preferred option for achieving prompt, predictable blood levels. Subcutaneous administration is not commonly used for Penicillin G, and oral administration is generally ineffective due to gastric degradation.