Which agent is used for life-threatening ventricular arrhythmias?

Which agent is used for life-threatening ventricular arrhythmias?

• A. Amiodarone
• B. Digoxin
• C. Sotalol
• D. Lidocaine

Answer: (D)

Lidocaine is a class IB antiarrhythmic used for life-threatening ventricular arrhythmias because it preferentially blocks fast sodium channels in depolarized, ischemic ventricular tissue. This targets the abnormal automaticity and ectopic foci that drive dangerous ventricular rhythms, especially during acute myocardial ischemia or infarction. Its action reduces ectopic activity in Purkinje and ventricular tissue, shortens the action potential in diseased cells, and has a rapid IV onset, making it effective for acute management. While other drugs like amiodarone are also used, lidocaine’s effectiveness in ischemic ventricles and its quick, short-acting profile make it a preferred option in emergent settings.

Lidocaine is a class IB antiarrhythmic used for life-threatening ventricular arrhythmias because it preferentially blocks fast sodium channels in depolarized, ischemic ventricular tissue. This targets the abnormal automaticity and ectopic foci that drive dangerous ventricular rhythms, especially during acute myocardial ischemia or infarction. Its action reduces ectopic activity in Purkinje and ventricular tissue, shortens the action potential in diseased cells, and has a rapid IV onset, making it effective for acute management. While other drugs like amiodarone are also used, lidocaine’s effectiveness in ischemic ventricles and its quick, short-acting profile make it a preferred option in emergent settings.