Which drug ends with -liptin and is a DPP-4 inhibitor used in Type II diabetes mellitus?

Which drug ends with -liptin and is a DPP-4 inhibitor used in Type II diabetes mellitus?

• A. Sitagliptin
• B. Metformin
• C. Glipizide
• D. Acarbose

Answer: (A)

DPP-4 inhibitors work by blocking the enzyme that degrades incretin hormones, which boosts glucose-dependent insulin secretion and suppresses glucagon after meals. A naming clue is that many of these drugs end with -liptin. Sitagliptin fits both the pattern and the mechanism, making it a DPP-4 inhibitor used in Type 2 diabetes mellitus. The other options belong to different drug classes—metformin is a biguanide, glipizide is a sulfonylurea, and acarbose is an alpha-glucosidase inhibitor—so they do not match the -liptin/DPP-4 inhibitor profile.

DPP-4 inhibitors work by blocking the enzyme that degrades incretin hormones, which boosts glucose-dependent insulin secretion and suppresses glucagon after meals. A naming clue is that many of these drugs end with -liptin. Sitagliptin fits both the pattern and the mechanism, making it a DPP-4 inhibitor used in Type 2 diabetes mellitus. The other options belong to different drug classes—metformin is a biguanide, glipizide is a sulfonylurea, and acarbose is an alpha-glucosidase inhibitor—so they do not match the -liptin/DPP-4 inhibitor profile.