Which pairing is correct regarding antibiotic and adverse effect?

Which pairing is correct regarding antibiotic and adverse effect?

• A. Clindamycin — aplastic anemia
• B. Erythromycin Estolate — aplastic anemia
• C. Penicillin G — aplastic anemia
• D. Chloramphenicol — aplastic anemia

Answer: (D)

Bone marrow suppression is a potential adverse effect of some antibiotics, and chloramphenicol is the classic example linked to aplastic anemia. This serious condition involves pancytopenia from bone marrow failure, and with chloramphenicol the reaction is often idiosyncratic and not dose-dependent, making it irreversible in many cases. The drug’s action on bacterial ribosomes is its therapeutic effect, but it can also affect mitochondrial ribosomes in human cells, including hematopoietic cells, contributing to the risk of aplastic anemia. Other antibiotics have different common adverse effects: clindamycin is most notorious for causing C. difficile–associated colitis; erythromycin estolate is linked to hepatotoxicity and cholestasis; penicillin G typically leads to hypersensitivity reactions and related hematologic issues but not classic aplastic anemia. Therefore, the pairing chloramphenicol with aplastic anemia is the correct match.

Bone marrow suppression is a potential adverse effect of some antibiotics, and chloramphenicol is the classic example linked to aplastic anemia. This serious condition involves pancytopenia from bone marrow failure, and with chloramphenicol the reaction is often idiosyncratic and not dose-dependent, making it irreversible in many cases. The drug’s action on bacterial ribosomes is its therapeutic effect, but it can also affect mitochondrial ribosomes in human cells, including hematopoietic cells, contributing to the risk of aplastic anemia.

Other antibiotics have different common adverse effects: clindamycin is most notorious for causing C. difficile–associated colitis; erythromycin estolate is linked to hepatotoxicity and cholestasis; penicillin G typically leads to hypersensitivity reactions and related hematologic issues but not classic aplastic anemia. Therefore, the pairing chloramphenicol with aplastic anemia is the correct match.