Which statement about ARBs is true?

Which statement about ARBs is true?

• A. They are used to treat hypertension by blocking Angiotensin II receptors
• B. They end in -Pril
• C. They inhibit ACE
• D. They stimulate aldosterone secretion

Answer: (A)

ARBs work by blocking the angiotensin II type 1 receptors, so the hormone angiotensin II cannot exert its usual effects like vasoconstriction and triggering aldosterone release. This receptor blockade lowers blood pressure and reduces sodium and water retention. They do not inhibit the angiotensin‑converting enzyme (that’s what ACE inhibitors do), and they do not have the “-Pril” suffix that marks ACE inhibitors; instead, ARBs are typically named with the “-sartan” ending. Because Ang II’s action is blocked at the receptor, aldosterone secretion tends to decrease rather than increase, although the body may transiently raise Ang II levels due to feedback. This mechanism underpins their use in hypertension and related conditions, with some patients preferring ARBs when ACE inhibitors cause cough or angioedema.

ARBs work by blocking the angiotensin II type 1 receptors, so the hormone angiotensin II cannot exert its usual effects like vasoconstriction and triggering aldosterone release. This receptor blockade lowers blood pressure and reduces sodium and water retention. They do not inhibit the angiotensin‑converting enzyme (that’s what ACE inhibitors do), and they do not have the “-Pril” suffix that marks ACE inhibitors; instead, ARBs are typically named with the “-sartan” ending. Because Ang II’s action is blocked at the receptor, aldosterone secretion tends to decrease rather than increase, although the body may transiently raise Ang II levels due to feedback. This mechanism underpins their use in hypertension and related conditions, with some patients preferring ARBs when ACE inhibitors cause cough or angioedema.