Which statement about SGLT2 inhibitors is true?

Which statement about SGLT2 inhibitors is true?

• A. They inhibit breakdown of incretin hormones
• B. They inhibit reabsorption of glucose in the proximal tubule
• C. They increase insulin secretion
• D. They prevent reabsorption of glucose in the proximal tubule

Answer: (B)

SGLT2 inhibitors lower blood glucose by blocking glucose reabsorption in the kidney’s proximal tubule, causing glucose to spill into the urine. In the proximal tubule, most filtered glucose is reabsorbed via the SGLT2 transporter; inhibiting this transporter reduces reabsorption and increases urinary glucose excretion, which lowers plasma glucose. This mechanism is independent of insulin secretion, and these drugs do not affect the breakdown of incretin hormones. So the true description is that they inhibit reabsorption of glucose in the proximal tubule.

SGLT2 inhibitors lower blood glucose by blocking glucose reabsorption in the kidney’s proximal tubule, causing glucose to spill into the urine. In the proximal tubule, most filtered glucose is reabsorbed via the SGLT2 transporter; inhibiting this transporter reduces reabsorption and increases urinary glucose excretion, which lowers plasma glucose. This mechanism is independent of insulin secretion, and these drugs do not affect the breakdown of incretin hormones. So the true description is that they inhibit reabsorption of glucose in the proximal tubule.